发明名称 |
Development of a live, attenuated, recombinant vaccine for Brucellosis |
摘要 |
A recombinant, attenuated strain of Brucella suis or Brucella melitensis with a deficiency in carboxyl-terminal protease activity or tail-specific protease activity can be used as a vaccine for the prevention or treatment of Brucellosis. Prior exposure to the Brucella species is identified by detecting a genetic sequence for carboxyl-terminal (i.e. tail-specific) protease activity in a biological sample.
|
申请公布号 |
US7364745(B2) |
申请公布日期 |
2008.04.29 |
申请号 |
US20050246957 |
申请日期 |
2005.10.11 |
申请人 |
VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. |
发明人 |
BANDARA ALOKA B.;BOYLE STEPHEN M.;SRIRANGANATHAN NAMMALWAR;SCHURIG GERHARDT G. |
分类号 |
A61K39/10;C12N15/74 |
主分类号 |
A61K39/10 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|