发明名称 |
PROCESS FOR THE PREPARATION OF INSULIN CONJUGATES |
摘要 |
The invention claims a process for making an insulin-oligomer conjugate IN-105. IN-105 precursor having formula G-A-V-R-[B-Chain]-R-D-A-D-D-R-[A-Chain] is cloned and expressed in Pichia. The biosynthetic precursor is then conjugated with an activated oligomer. The IN-105 precursor-oligomer conjugate is then treated with protease and purified to afford active insulin-oligomer conjugate of formula insulin-OC-CH2-CH2-(OCH2CH2) 3-OCH3.
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申请公布号 |
KR20080067625(A) |
申请公布日期 |
2008.07.21 |
申请号 |
KR20087009648 |
申请日期 |
2008.04.22 |
申请人 |
BIOCON LIMITED |
发明人 |
DAVE NITESH;HAZRA PARTHA;GOEL ANUJ;ROY NITA;KHEDKAR ANAND;IYER HARISH;KRISHNAN GAUTAM;MANJUNATH H. S.;SURYANARAYAN SHRIKUMAR;MANIKAM GOVINDASAMY;SACHDEV GOLDY;GARG MAYANK |
分类号 |
C07K14/62 |
主分类号 |
C07K14/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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