2-SUSTITUTED AMINOALKYLENYLOXY-3-SUBSTITUTEDPHENYLETHYNYL QUINOXALINE DERIVATIVES

摘要

Provided is a 2-substituted aminoalkylenyloxy-3-substituted phenylethynyl quinoxaline derivative, capable of suppressing expression of a WNT gene and proliferation of a cancer cell. A 2-substituted aminoalkylenyloxy-3-substituted phenylethynyl quinoxaline derivative is represented by the formula 1. In the formula 1, Y and Z is independently a hydrogen atom, halogen atom, C1-C8 alkyl group, or a C1-C8 alkoxy group; and R shows -X-Het. or -X-NR1R2, in which X is a C1-C8 alkylene group or a C2-C8 alkylene oxyalkylene group, and R1 and R2 is independently a hydrogen atom, C1-C8 alkyl group, or a pentagon or heptagon hetero group in which a hetero atom selected from another nitrogen atom or an oxygen atom with the nitrogen boned to the R1 and R2 is included.