| 摘要 |
PROBLEM TO BE SOLVED: To provide methods and compositions for the treatment of metabolic disorders, particularly for the treatment for prevention and reduction of an elevated blood glucose level.SOLUTION: The present invention provides use of modified oligonucleotides having a nucleobase sequence at least 90% complementary to a nucleobase sequence of miR-103 and/or miR-107 in the production of a pharmaceutical for use in (i) reducing a blood glucose level in a subject or (ii) preventing or delaying the onset of an elevated blood glucose level in the subject.SELECTED DRAWING: None |
