CYCLIC RENIN INHIBITORS CONTAINING 2-SUBSTITUTED(3S, 4S)-4-AMINO-5-CYCLOHEXYL-3-HYDROXY PENTANOIC ACID, 2-SUBSTITUTED (3S, 4S)-5-CYCLOHEXYL-3,4-DIHYDROXY-PENTANOIC ACID OR 2 -SUBSTITUTED (4S, 5S)-5-AMINO-6- YCLOHEXYL-4-HYDROXYHEXANOIC ACID OR ITS ANALOGS

摘要

3/MRD2 12/MRD11 13/MRD12 14/MRD13 17784IB TITLE OF THE INVENTION CYCLIC RENIN INHIBITORS CONTAINING 2-SUBSTITUTED (3S,4S)-4-AMINO-5-CYCLOHEXYL-3-HYDROXY PENTANOIC ACID, 2-SUBSTITUTED (3S,4S)-5-CYCLOHEXYL-3,4-DI HYDROXYPENTANOIC ACID OR 2-SUBSTITUTED (4S,5S)-5-AMINO-6-CYCLOHEXYL-4-HYDROXYHEXANOIC ACID OR ITS ANALOGS Compounds of the formula: (I) 3/MRD2 12/MRD11 13/MRD12 14/MRD13 -i- l7784IB are disclosed. These compounds inhibit the angiotensinogen-cleaving action of the natural proteolytic enzyme, renin, are useful in treating, preventing or managing renin-associated hypertension, hyperaldosteronism, congestive heart failure, and glaucoma.