Measurement of cytoskeletal proteins and uses thereof in diagnosis, prognosis and therapy

摘要

The present invention relates to monitoring patients for an inflammatory condition or infection (preferably wound infection) by testing an extracellular fluid such as a wound fluid for an elevated level of: (i) vimentin; (ii) a vimentin breakdown product; or (iii) a marker indicative of the presence of vimentin. The present invention provides methods of diagnosis and prognosis, wound dressings, devices (e.g. biosensors) and kits for use in such methods.

主权项

1. A method for the treatment of a mammalian wound comprising the steps of measuring in a wound fluid the presence or level of a marker in a wound fluid collected from the wound, and applying an antimicrobial wound dressing to the wound selectively if the presence or level of said marker is indicative of an infection in the wound, wherein the marker is a cytoskeletal component or a breakdown product thereof, further wherein the marker is indicative of an infection in the wound if the level of the marker is elevated.