| 摘要 |
PURPOSE:To treat infectious diseases with fungi by culturing a specific bacterium in a medium. CONSTITUTION:A Streptomyces sp. A-401 capable of producing antibiotic TAN-1,254 is subjected to submerged aerated culture in a medium containing glucose, meat essence, etc., at 10-30 deg.C approximately at pH of neutrality to give a culture mixture. Then, the culture mixture is extracted with an organic solvent and purified by column chromatography to produce antibiotic TAN-1,254 having the following physical and chemical properties of appearance: white powder; specific rotatory power: value shown by formula I; mass spectrum values (SIMS method):m/z 382(M+N) ; molecular formula: C14H19N7O8; elemental analysis value: values shown by formula II (calculated as C14N7O8 H2O) ; ultraviolet absorption spectrum: values shown by formula III; H nuclear magnetic resonance spectrum: values shown by formula IV; 13C nuclear magnetic resonance: values shown by formula V, etc., or a salt thereof. |
