CONTROLLED-RELEASE LIPOSOME DELIVERY SYSTEM

摘要

A method for selectively controlling the rate of release of a liposome-entrapped compound from an intramuscular or subcutaneous injection site. The method includes selecting the average size, amount, and lipid composition of liposomes injected into the site to produce a desired half life of release of the compound. A preferred composition used in practicing the invention includes an aqueous suspension of liposomes containing the compound in entrapped form, and having average particle sizes less than about 0.3 microns, and larger empty liposomes present in an amount effective to increase the half life of release of the compound from the injection site to a desired half life between about 1-14 days. Also disclosed is a stable liposome/calcitonin composition.