Amino acid derivatives, method for their preparation and their therapeutic application.

摘要

Amino acid drivatives, enkephalinase and ACE inhibitors, of the formula (Ia) and (Ib), wherein R1 represents a biphenyl group or one of the groups (a), wherein Z, Y and n have the meanings (b) or (c), wherein R'1, represents a hydrogen atom, a lower alkyl group; a phenyl group; a lower phenylalkylene group. R2 represents a hydrogen atom; a lower alkyl group; a lower hydroxyalkylene group; a lower phenylalkylene group; a lower hydroxyphenylalkylene group; a lower aminoalkylene group; a lower guanidinoalkylene group; a lower mercaptoalkylene group; a lower thioalkylene lower alkyl group; a lower imidazolylkylene group; a lower indolylalkylene group; a lower carbamylalkylene group; a lower carboxyalkylene group or one of the groupings (d), where Z, Y and n have the meanings (e), X indicates a grouping responsible for chelating the zinc atom of enzymes, enkephalinase and ACE, and may be selected from the group which comprises a mercaptomethyl; hydroxamic acid; an N-carboxyalkyl of the formula (f), wherein R3 represents a benzyl lower alkyl radical, or a benzyl lower alkoxy radical; phosphorus-containing derivatives of the formula (g) or (h).