New bi:phenyl:methyl-substd. imidazole derivs.

摘要

Biphenylylmethyl-imidazole derivs. (I) and their 1- and 3-isomer mixtures and addn. and base salts are new. Where A1-A4 = H or CH and one or two = N; r1 = H; F; Cl; Br; OH; 1-3C alkyl; 1-3C alkoxy; amino opt. mono- or disubstd. by 1-6C alkyl, phenyl, 5-7C cycloalkyl, phenyl-1-3C alkyl or 5-7C cycloalkyl-1-3C alkyl; acylamino opt. 3-, 4-, 5-, 6- or 7-halo or hydroxy-substd. when acyl gp. is 1-7C alkanoyl; 2-4C alkoxycarbonyl; 1-6C alkanesulphonyl; benzoyl, benzenesulphonyl, 2-carboxy-cyclohexylcarbonyl, 2-aminocarbonyl-cyclohexylcarbonyl, 5-7C cycloalkylcarbonyl, phenyl-1-4C alkanoyl or 5-7C cycloalkyl-1-4C alkanoyl in which a phenyl gp, is opt. mono- or disubstd. by F, Cl, Br, CH3 or CH3O; a 3-5C alkylsultame gp.; pyrrolidino, piperidino or hexamethyleneimino opt. substd. by 1-3C alkyl, carboxyl-1-3C alkyl or oxo; opt. hydrogenated phthalimido or 2-oxo-isoindolin-1-yl; or -N(R6)-CO-N(R7)(R8); R2 = H or 1-3C alkyl; R3 = 1-6C alkyl; R4 = COOH, CN, 1H-tetrazolyl, 1-triphenylmethyl-tetrazolyl or 2-5C alkoxycarbonyl; R5 = H, F, Cl or Br; R6, R7 = H, 1-8C alkyl, 5-7C cycloalkyl, 5-7C cycloalkyl-1-3C alkyl or phenyl or phenyl-1-3C alkyl opt. mono- or disubstd. by OH or 1-3C alkoxy, or R6 + R7 = ethylene or propylene; R8 = H, 1-8C alkyl, 5-7C cycloalkyl, 5-7C cycloalkyl-1-3C alkyl, phenyl or phenyl-1-3C alkyl opt. mono- or disubstd. by OH or 1-3C alkoxy, 2-(Cl or Br)-ethyl, 3-(Cl or Br)-propyl or, when R6 + R7 = ethylene or propylene, also dialkylaminocarbonyl; except cpds. (I) where R1 = R2 = R5 = H, R3 = n-butyl, R4 = COOH and (i) one of A1-A4 = N and the remainder = CH, (ii) A2 and A4 or A1 and A3 = N and the remainder = CH, (iii) A4 = N, A3 = HO-C or CH3O-C and A1 = A2 = CH or (iv) A4 = N, A1 = CH3-C and A2 = A3 = CH.