发明名称 |
COMBINED CHEMO-IMMUNOTHERAPY WITH LIPOSOMAL DRUGS AND CYTOKINES |
摘要 |
A method of antitumor therapy is described in which administration of a chemotherapeutic drug, encapsulated in liposomes, is supplemented by administration of an immunostimulating cytokine. The cytokine is preferably also encapsulated in liposomes. In tumor models for lung and colon carcinomas, this method produced a significantly greater therapeutic effect, as evidenced by survival rate and tumor size, than a combination of the effects produced by the free or liposome-encapsulated components administered individually.
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申请公布号 |
CA2312778(A1) |
申请公布日期 |
1999.06.10 |
申请号 |
CA19982312778 |
申请日期 |
1998.12.01 |
申请人 |
HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.;YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALE M |
发明人 |
KEDAR, ELIEZER;BARENHOLZ, YECHEZKEL;GABIZON, ALBERTO A. |
分类号 |
A61K9/127;A61K31/21;A61K31/4745;A61K31/704;A61K33/24;A61K38/00;A61K38/19;A61K38/20;A61K38/21;A61K45/00;A61K47/10;A61K47/16;A61K47/24;A61P35/00;(IPC1-7):A61K9/127;A61K48/00;A61K51/08;A61K51/12 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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