| 摘要 |
PCT No. PCT/US97/14119 Sec. 371 Date Mar. 10, 1998 Sec. 102(e) Date Mar. 10, 1998 PCT Filed Aug. 8, 1997 PCT Pub. No. WO98/06381 PCT Pub. Date Feb. 19, 1998Disclosed are preservative systems useful in aqueous pharmaceutical compositions containing an active agent and a cyclodextrin. The preservative systems comprise boric acid and one or more compounds selected from the group consisting of C16 benzalkonium halide compounds, polymeric quatemary ammonium compounds, and quatemary ammonium alkylene glycol phospholipid derivatives of the following structure where a+b=3; R1 is C8-C22 alkyl or alkene; X is NH, O, or CH2; R2 is C2-C6 alkyl; each R3 is independently C1-C12 alkyl or alkene; and Y is nothing or C1-C6 alkyl or alkene; and pharmaceutically acceptable salts thereof.
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