| 摘要 |
<p>Methods, kits, apparatus, and compositions for inhibiting a cerabral neurovascular disorder or a muscular headache in a human patient, are provided. The methods comprise intranasal administering to the patient, a pharmaceutical composition comprising a local anesthetic, and preferably a long-acting local anesthetic ingredient. A composition useful for practicing the methods of the invention is described which comprises at least one local anesthetic in a pharmaceutically acceptable carrier, wherein the composition is formulated for intranasal delivery. Cerebral neurovascular disorders include migraine and cluster headache. Muscular headaches include tension headaches and muscle contraction headaches. A kit comprising the composition, an intranasal applicator (103), and a method of systemically delivering a pharmaceutically active agent to an animal are also included in the invention. Apparatus (100) for delivering or applying the compositions of the invention or for performing the methods of the invention are also described.</p> |
