| 摘要 |
PROBLEM TO BE SOLVED: To provide a transdermal absorption therapeutic system having improved compliance, adhesion, tolerability and/or safety properties, and having specific release profiles, and to provide a method for manufacturing it and a method for using it.SOLUTION: The present invention relates to the Transdermal absorption Therapeutic System (TTS) comprising: a) a backing layer; b) a reservoir layer comprising one or more active ingredients, such as tacrine, rivastigmine, donepezil, galantamine, and the like, and one or more polymers, such as acrylates, styrene-isoprene-styrene block copolymers, and the like; c) an adhesive layer comprising a silicone polymer and a tackifier, such as silicone oils and the like; providing a maximum plasma concentration of about 2.5 to 20 ng/ml from a mean of about 4 to 12 hours after application. The present invention also relates to the method for manufacturing the system by a flow coating method and the method for the prevention, treatment or delay of progression of Alzheimer's disease using the system. Preferably, the TTS has an adhesive layer that exhibits an adhesive force between 10 N/TTS and 150 N/TTS.SELECTED DRAWING: None |
