发明名称 |
POLYNUCLEOTIDE BINDING PROTEIN SEQUENCING CROSS REFERENCE TO RELATED APPLICATIONS |
摘要 |
The present disclosure relates to systems, methods and compositions for single molecule electronic sequencing of template nucleic acids using nanosensors. The nanosensors of the invention improve the measurement of polynucleotides by assimilating authentic polynucleotide binding proteins ("PBPs") in place of conventional pore-forming proteins that do not normally interact with polynucleotides. The PBPs of the present invention form the constriction sites of electroconductive pores of the nanosensors, while maintaining their natural polynucleotide binding and processing activities. |
申请公布号 |
WO2016141221(A1) |
申请公布日期 |
2016.09.09 |
申请号 |
WO2016US20752 |
申请日期 |
2016.03.03 |
申请人 |
STRATOS GENOMICS, INC. |
发明人 |
KOKORIS, Mark, Stamatios;MCRUER, Robert, N. |
分类号 |
C12Q1/68;A61K31/713;C12P19/34;C12Q1/34;C12Q1/48;G01N27/26;G01N27/447;G01N33/487 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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