N-MONOSUBSTITUTED ADAMANTYL/NORBORNANYL 17_BETA-CARBAMIDES OF 3-CARBOXY-ANDROSTS-3,5-DIENES AS TESTOSTERONE 5 ALPHA-REDUCTASE INHIBITORS

摘要

8358/SCM95 18112 TITLE OF THE INVENTION N-MONOSUBSTITUTED ADAMANTYL/NORBORNANYL 17.beta.-CARBAMIDES OF 3-CARBOXY-ANDROST-3,5-DIENES AS TESTOSTERONE 5a-REDUCTASE INHIBITORS N-MONOSUBSTITUTED ADAMANTYL/NORBORNANYL 17.beta.-CARBAMIDES OF 3-CARBOXY-ANDROST-3,5-DIENES AS TESTOSTERONE 5a-REDUCTASE INHIBITORS OF THE FORMULA: I 8358/SCM95 18112 wherein R is a hydrocarbon radical selected from substituted or unsubstituted 1- or 2-adamantyl or 1-, 2 or 7-norbornanyl and pharmaceutically acceptable salts or esters thereof. Also described is a pharmaceutical formulation. The above compounds are active as testosterone 5a-reductase inhibitors and thus are useful topically for treatment of acne, seborrhea, female hirsutism, and systemically in treatment of benign prostatic hypertrophy.