| 摘要 |
<p>NEW MATERIAL:Optically active compounds of formula I [R1 and R2 are H, 1-4C alkyl; R3 is 1-4C alkyl; R4 is CH2OR7 or formula II, R7 is H or protective group for OH; R8 is H, OR, 1-4C alkyl or 1-4C alkoxy; R5 is OH or O together with R4; Y and Z are direct bond between them or H respectively; R6 is COOR9 Ar C(OR)R10R11; R9-R11 are H or 1-4C alkyl; Steric configuration of carbon atom at chiral center denoted by and steric configuration in case cyclic carbon atom introduced by addition of water is chiral center carbon atom are selectively one of S- and R-form]. EXAMPLE:(2R,4R)-1,2,8-trihydroxy-4,8-dimethyl-4-vinyl-nonane. USE:An intermediate capable of readily mass-producing (+)- or (-)-bakuchiol having a high ratio of chiral center introduction and useful as an ingigorating drug, etc., in a short process. PREPARATION:An optically active compound of formula I is obtained from an optically active compound of formula III through optically active compounds of formulae IV-V.</p> |
