Neue 2-Chlor- und 1,2-Dichlorsteriode

摘要

2-Chloro-DELTA1,4-steroids of formula : (where R1 is H or CH3; R2 is H, free or esterified OH; X is F, Cl or CH3; Y is H or halogen; Z is halogen of atomic wt. = Y, OH in beta-posn. or when Y is H, Z is an OH in alpha-posn.). A prefd. cpd. is 6alpha-fluoro-1alpha,2beta-dichloro-11beta-hydroxy-21-acetoxy-16a- lpha-methyl-4-pregnene-3,20-dione. Cpds. useful as anti-inflammatories.