2-Amino-3-carbamido-quinoxaline-di-N-oxides of the formula ARE PRODUCED BY HYDROLISING THE CORRESPONDING 2-AMINO-3-CYANOQUINOXALINE-DI-N-oxides of the formula IN AN ACIDIC SOLUTION WHEREIN R is hydrogen, halogen, lower alkyl or lower alkoxy. The compounds are useful in treatment of infections from gram positive and gram negative bacteria and are administered in the general range of 25 mg/kg orally or parenterally.