| 摘要 |
Acylated derivatives of kallikrein-trypsin-inhibitor (KTI) are reacted with cyanates such as potassium cyanate or O-alkylisoureas, such as O-methylisourea, to produce an urea derivative of the acylated KTI in which the epsilon -amino group of the lysine residue in position 15 of the KTI is replaced by an urea or guanidine group. The urea derivatives of the acylated KTI are found to be as effective therapeutically and for the same proposes as KTI itself, but contrary to KTI are not very extensively accumulated in the kidneys and thus provide a long-lasting high level in the blood. Since they are excreted with the urine they are particularly useful in the treatment of diseases of the urogenital tract. |
