A PROCESS FOR PREPARING A SPIRO COMPOUND

摘要

A compound of formula I, having antibacterial activity and a pharmaceutical composition containing the compound of formula I: wherein a represents an integer equal to 0 or 1; b represents an integer equal to 2 through 5, inclusive; c represents an integer equal to 0 or 1; and d represents an integer equal to 0 through 2, inclusive; Z represents @CHR<1>, @NR<2>, @C=NOR<3>, an oxygen atom or a sulfur atom, wherein R<1> represents a hydrogen atom, an amino group, a monoalkylamino group of 1 to 6 carbon atoms, a dialkylamino group containing 1 to 6 carbon atoms per alkyl, a hydroxyl group, an alkoxy group of 1 to 6 carbon atoms or a hydroxyalkyl group of 1 to 6 carbon atoms; R<2> represents a hydrogen atom, an alkyl group of 1 to 6 carbon atoms, a hydroxyalkyl group of 1 to 6 carbon atoms, a haloalkyl group of 1 to 6 carbon atoms, a formyl group or an alkylcarbonyl group of 2 to 7 carbon atoms; and R<3> represents a hydrogen atom or an alkyl group of 1 to 6 carbon atoms; Q represents a partial structure of formula II: wherein R<4> represents an alkyl group of 1 to 6 carbon atoms, an alkenyl group of 2 to 6 carbon atoms, a haloalkyl group of 1 to 6 carbon atoms, a substituted or unsubstituted cycloalkyl group of 3 to 6 carbon atoms, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, an alkoxy group of 1 to 6 carbon atoms or an alkylamino group of 1 to 6 carbon atoms; R<5> represents a hydrogen atom or an alkyl group of 1 to 6 carbon atoms; R<6> represents a hydrogen atom, a substituted or unsubstituted amino group, a hydroxyl group, an alkoxy group of 1 to 6 carbon atoms or a halogen atom; A represents a nitrogen atom or @C-R<7>, wherein R<7> represents a hydrogen atom, an alkyl group of 1 to 6 carbon atoms, a halogen atom, an alkoxy group of 1 to 6 carbon atoms, a haloalkyl group of 1 to 6 carbon atoms or a cyano group; R<4> may, taken together with R<5> and/or R<7>, form a substituted or unsubstituted ring which can include an oxygen, nitrogen or sulfur atom, wherein the substituent is an alkyl group of 1 to 6 carbon atoms or a haloalkyl group of 1 to 6 carbon atoms; X represents a halogen atom; Y represents a hydrogen atom, an alkyl group of 1 to 6 carbon atoms, an alkoxyalkyl group of 1 to 6 carbon atoms, a phenylalkyl group containing 1 to 6 carbon atoms in its alkyl moiety, a dihaloboron group, a phenyl group, an acetoxymethyl group, a pivaloyloxymethyl group, an ethoxycarbonyloxy group, a choline group, a dimethylaminoethyl group, a 5-indanyl group, a phthalidinyl group, a 5-substituted-2-oxo-1,3-dioxazol-4-ylmethyl group or a 3-acetoxy-2-oxobutyl group, or a salt thereof.