Method of making a diastereomeric mixture containing two diastereomeric N-acyl-amino acid esters

摘要

In the process of hydrocarboxylating an alpha -enamide with CO and an organic hydroxyl compound to produce a N-acyl- alpha -amino acid ester, the improvement comprising using as the organic hydroxyl compound reactant, an organic hydroxyl compound which has a chiral center that is essentially all L or D, thereby producing a reaction mixture having essentially no enantiomeric pairs and containing diastereomeric N-acyl- alpha -amino acid esters having two chiral centers.