| 摘要 |
<p>NEW MATERIAL:A compound (salt) expressed by formulaI(R<1> is H or a protecting group of the carboxyl group; R<2> is aryl, acylamino, triazolyl, tetrazolyl, etc.; R<3> is H or lower alkoxyl; R<4> is H or halogen; R<5> is H or amino group which may be protected or substituted). EXAMPLE:7-[2- ( 2-Chloroacetamidothiazol-4-yl ) glyoxylamido]-3-[2-( 5-methyl- 1,2,3,4-tetrazolyl)methyl]-DELTA<3>-cephem-4-carboxylic acid. USE:An intermediate for preparing antimicrobial agents. PROCESS:A 7-aminocephalosporin expressed by formula II is reacted with a thiazol-4-ylglyoxylic acid derivative expressed by formula III in the presence of an acid, etc. in an organic solvent to give the compound expressed by formulaI. An antimicrobial agent expressed by formula IV (R<6> is H or alkyl) is further obtained from the resultant compound expressed by formulaI.</p> |
