摘要 |
Synthetic peptides (A), of 13-33 amino acids (aa) when monomeric or 26-66 when dimeric (either linear or cyclised by Cys-Cys-disulphide bonds), have formula (I): DELTA -Z-Trp-Gly-Cys-th-Cys-Tyr-Ser- OMICRON (I) DELTA = biotinyl, biocytinyl, hydrogen, acetyl, aliphatic chain (preferably 1-6 C alkyl, or 2-6 C alkenyl or aminoalkylcarbonyl) , optionally containing 1 or 2 mercapto, formyl or amino groups; Z = x1-(Ser, Gln or Asn)-x2; x1 = 0-9 aa; x2 = 0-5 aa; th = -AA1-AA2-AA3-AA4-AA5-; AA1 = Lys, Arg or Thr; AA2 = Gly or Asn; AA3 = Lys, Arg or ornithine (Orn); AA4 = Leu, Ala, Ile or Gln; AA5 = Ile, Val, Leu, Thr, norleucine (Nle) or norvaline (Nva); provided that AA1-AA5 is not Lys-Gly-Lys-Leu-(Ile or Val); OMICRON , attached to carbonyl of Ser, = hydroxy, amino, 1-6 C alkoxy, Val- EPSILON - phi , -Z-Trp-Gly-Cys-th-Cys-Tyr-Thr-Ser- theta , or Val- EPSILON -Z-Trp-Gly-Cys-th-Cys-Tyr-Thr-Ser-Val- EPSILON - theta ; EPSILON , optionally absent, = AA6-Trp-(Asn or His)-AA7-AA8; AA6 = aa other than Lys; AA7 = any aa; AA8 = Ser or Thr; phi , attached to carbonyl on AA8,Val or Ser, = OH, amino or 1-6 C alkoxy.
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