发明名称 |
1,3-diheterocyclic metalloprotease inhibitors |
摘要 |
Disclosed are compounds which are inhibitors of metalloproteases having the following structure: where Ar, W, X, Y, Z, R1 and R2 have the meanings described in the specification and optical isomers, diastereomers, and enantiomers thereof or a pharmaceutically-acceptable salt, or biohydrolyzable amides, esters, or imides thereof. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by unwanted metalloprotease activity using these compounds or pharmaceutical compositions.
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申请公布号 |
US6150370(A) |
申请公布日期 |
2000.11.21 |
申请号 |
US19970918419 |
申请日期 |
1997.08.26 |
申请人 |
THE PROCTER & GAMBLE COMPANY |
发明人 |
PIKUL, STANISLAW;MCDOW-DUNHAM, KELLY LYNN;ALMSTEAD, NEIL GREGORY;DE, BISWANATH;NATCHUS, MICHAEL GEORGE;TAIWO, YETUNDE OLABISI |
分类号 |
A61K31/426;A61K31/495;A61K31/527;A61K31/54;A61K31/5517;A61P1/02;A61P1/12;A61P11/06;A61P17/02;A61P27/02;A61P29/00;A61P35/00;A61P43/00;C07D233/02;C07D233/38;C07D239/04;C07D239/06;C07D239/10;C07D243/04;C07D265/06;C07D265/14;C07D277/06;C07D279/06;C07D409/14;C07D413/14;C07D487/04;C07D495/10;(IPC1-7):A61K31/505;C07F9/02;C07D239/00;C07D487/00 |
主分类号 |
A61K31/426 |
代理机构 |
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代理人 |
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地址 |
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