| 摘要 |
PURPOSE:To produce the title compound useful as a raw material for macrocyclic lactone, polymer raw material, etc., in high selectivity and in high yield by bringing a readily obtainable long-chain diacid monoester as a raw material into contact with hydrogen in the presence of water and a solid catalyst under a mild reaction condition. CONSTITUTION:A long-chain diacid monoester (e.g. pentadecane diacid monomethyl ester) shown by formula I (R is alkyl; n is 8-16C integer) is brought into contact with hydrogen in the presence of water and a solid catalyst (especially ruthenium-based and/or rhenium-based catalyst, specially preferably ruthenium, tin or rhenium) to advantageously give an omega-hydroxy fatty acid ester (e.g. omega-hydroxypentadecanoic acid methyl ester) shown by formula II. The starting compound shown by formula I is readily obtained by esterifying an alkane diacid with an alcohol, then converting into a barium mono salt and replacing the salt with an acid. The omega-hydroxy fatty acid ester is useful as a starting raw material for drugs and perfume and a raw material for polymers. |
