发明名称 |
Nanomolar beta-lactamase inhibitors |
摘要 |
New carboxyphenyl-glycylboronic acid transition-state analog inhibitors, representative of a class of compounds effective against class C beta-lactamase AmpC. The new compounds improve inhibition by over two-orders of magnitude compared to analogous glycylboronic acids, with Ki values as low as 1 nM.
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申请公布号 |
US7271186(B1) |
申请公布日期 |
2007.09.18 |
申请号 |
US20030731738 |
申请日期 |
2003.12.09 |
申请人 |
UNIVERSITY OF MODENA |
发明人 |
SHOICHET BRIAN K.;PRATI FABIO |
分类号 |
A61K31/425;A61K31/38;C07C233/00;C07D277/00;C07D277/04 |
主分类号 |
A61K31/425 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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