发明名称 |
MOLECULES WITH REDUCED HALF-LIVES, COMPOSITIONS AND USES THEREOF |
摘要 |
The present invention provides polypeptides containing at least the FcRn binding portion of an Fc region of an immunoglobulin molecule and that have altered amino acid sequences relative to wild type immunoglobulin molecules. The polypeptides have decreased in vivo serum half-lives and can be employe d in various methods. |
申请公布号 |
CA2665826(A1) |
申请公布日期 |
2008.04.24 |
申请号 |
CA20072665826 |
申请日期 |
2007.10.16 |
申请人 |
MEDIMMUNE, LLC |
发明人 |
WU, HERREN;DALL'ACQUA, WILLIAM |
分类号 |
C07K16/28;C07K16/30;C07K19/00 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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