The present invention relates to the identification of proteins located on the cell surface of dendritic cells or precursors thereof, particularly antigen presenting dendritic cells. In particular, the present invention relates to compounds such as antibodies that bind these proteins. These compounds can be used to detect and/or enrich a subset of dendritic cells or precursors thereof. These compounds can also be used to target antigens to dendritic cells or precursors thereof to modulate a humoral and/or T cell mediated immune response to an antigen, or used to target cytotoxic agents to dendritic cells or precursors thereof involved in diseased states.
申请公布号
CA2697448(A1)
申请公布日期
2009.03.05
申请号
CA20082697448
申请日期
2008.08.29
申请人
THE BURNET INSTITUTE;WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH
发明人
LAHOUD, MIREILLE HANNA;PROIETTO, ANNA IRENE;CAMINSCHI, IRINA;SHORTMAN, KEN;LEW, ANDREW MARK;WU, LI;WRIGHT, MARK DEXTER