The invention provides new methods of treatment using anti-scarring agents to inhibit scarring in humans, and also provides anti-scarring agents for new uses in the inhibition of scarring in humans. In a first incidence of treatment an anti-scarring agent is provided to each centimetre of a wound margin or each centimetre of a site at which a wound is to be formed in a first therapeutically effective amount; and in a subsequent incidence of treatment the anti-scarring agent is provided to each centimetre of wound margin in a larger therapeutically effective amount. The incidences of treatment occur between 8 hours and 48 hours apart from one another. The anti-scarring agent is preferably not TGF-ß3. The anti-scarring agent may be provided by intradermal injection. Also provided are kits and methods of selecting an appropriate treatment regime for inhibiting scarring associated with the healing of a human wound.
申请公布号
CA2709007(A1)
申请公布日期
2009.06.18
申请号
CA20082709007
申请日期
2008.12.11
申请人
RENOVO LIMITED
发明人
FERGUSON, MARK WILLIAM JAMES;O'KANE, SHARON;OCCLESTON, NICHOLAS;GOLDSPINK, NICHOLAS;NIELD, KERRY;SATTAR, ABDUL;BOANAS, ADAM;OWEN, KATE;BUSH, JAMES