发明名称 HYPERBARIC DEVICE AND METHODS FOR PRODUCING INACTIVATED VACCINES AND FOR REFOLDING SOLUBILIZING RECOMBINANT PROTEINS
摘要 The invention relates to hyperbaric devices for inactivating microorganisms and viruses while retaining their immunogenicity and for making and producing the soluble, disaggregated, refolded or active immunogenic or therapeutic proteins from inclusion bodies produced from prokaryotes or eukaryotes. The invention encompasses hyperbaric methods for inactivating pathogenic organisms, and methods for producing vaccine compositions using the inactivated pathogens. The hyperbarically inactivated microorganisms are safer and more immunogenic than chemically inactivated microorganisms. Similarly, the solubilized proteins have superior properties compared to more heavily aggregated proteins, including reduced non-specific immune reactions.
申请公布号 HK1211874(A1) 申请公布日期 2016.06.03
申请号 HK20160100050 申请日期 2016.01.05
申请人 MERIAL INC. 发明人 NICOLAS PIERRE, YVES CARBOULEC;GILDAS MERIAN;REN LABATUT;LIONEL GERENTES
分类号 A61K;A23L;C07K;C12N 主分类号 A61K
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