发明名称 |
SYNERGISTIC LIPOSOMAL FORMULATION FOR THE TREATMENT OF CANCER |
摘要 |
The present disclosure relates to the synergistic liposomal formulation comprising, phophatidylcholine, stearylamine and anticancer drugs for the treatment of cancer. The PC:SA cationic liposome encapsulated camptothecin (CPT) and doxorubicin (DOX) formulations show enhanced synergistic anti-cancer effect and provide improved therapeutic index as compared to either the liposome or drug alone. The present disclosure also relates to the use of Cationic liposomal preparation of phosphatidylcholine:stearylamine (PC:SA) showing anticancer effect. The SA-bearing liposome and drug entrapped in the liposome are effective against cancer both in vitro and in vivo, without causing any adverse effect on host. |
申请公布号 |
US2016228366(A1) |
申请公布日期 |
2016.08.11 |
申请号 |
US201415023107 |
申请日期 |
2014.09.18 |
申请人 |
COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH |
发明人 |
Ali Nahid;De Manjarika;Sen Triparna |
分类号 |
A61K9/127;A61K31/704;A61K31/542;A61K9/00;A61K47/24;A61K47/18 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
1. A synergistic liposomal formulation for the treatment of cancer wherein the formulation comprises, phophatidylcholine, stearylamine and anticancer drugs. |
地址 |
New Delhi IN |