| 发明名称 |
HUMAN CTLA-4 ANTIBODIES AND THEIR USES |
| 摘要 |
The presently subject matter provides novel human sequence antibodies against human CTLA-4 and methods of treating human diseases, infections and other conditions using these antibodies. |
| 申请公布号 |
US2016257753(A1) |
申请公布日期 |
2016.09.08 |
| 申请号 |
US201615163332 |
申请日期 |
2016.05.24 |
| 申请人 |
E.R. Squibb & Sons, L.L.C. |
发明人 |
Korman Alan J.;Halk Edward L.;Lonberg Nils;Deo Yashwant M.;Keler Tibor P. |
| 分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A monoclonal antibody or antigen-binding portion thereof, comprising a heavy chain variable region that comprises CDR1, CDR2, and CDR3 domains; and a light chain variable region that comprises CDR1, CDR2, and CDR3 domains, wherein the heavy chain variable region and light chain variable region CDR3 domains are selected from the group consisting of:
(a) a heavy chain variable region CDR3 comprising amino acids having the sequence set forth in SEQ ID NO:37; and a light chain variable region CDR3 comprising amino acids having the sequence set forth in SEQ ID NO:35; and (b) a heavy chain variable region CDR3 comprising amino acids having the sequence set forth in SEQ ID NO:38; and a light chain variable region CDR3 comprising amino acids having the sequence set forth in SEQ ID NO:36; and
wherein the antibody or antigen-binding portion thereof binds to human CTLA-4 with a binding affinity of about 108 M−1 or greater. |
| 地址 |
Princeton NJ US |
