| 摘要 |
1,169,696. 6-Aminopenicillanic acid. BEEOHAM GROUP Ltd. 31 Oct., 1966 [18 Nov., 1965], No. 48995/65. Heading C2A. Purified 6-aminopenicillanic acid, which does not elicit passive cutaneous anaphylactic reactions in suitably sensitized guinea pigs, is produced by treating an aqueous solution of 6-aminopenicillanic acid with a protein denaturing surfactant and then contacting it with one or more adsorbent materials and recovering the 6-APA from solution by precipitation at the isoelectric point of 4À3 pH. The preferred surfactant is sodium dodecylbenzene sulphonate. The adsorbents may be clays, earths, inorganic oxides, hydroxides or salts, silicates and activated carbons. In an example, Odex No. 1 detergent, which contains sodium dodecylbenzene sulphonate, is added to and then stirred 1 hour with an aqueous solution of 6-APA of pH 7À0; the solution is treated with Al(OH) 3 for ¢ hour, and then with activated carbon for ¢ hour, and the purified 6-APA recovered by adjusting the pH of the clarified solution to 4À3. Preferably, the process is carried out in an inert atmosphere such as nitrogen. |
