PROCESS FOR PRODUCING PEPTIDE

摘要

In the title processes, an ester of an N-protected amino acid or peptide with N-hydroxy-5-norbornene-2,3 dicarboxyimide is reacted with an amino acid or peptide having a free amino gp. in the presence of a carbodiimide. The reaction is effected with reduced racemisation and by product formation and may also be effected in an aq. medium. Prefd. processes lead to Pyroglu-His-ProNH2 and Pyroglu-His-Trp-Ser-Tyr-Gly-Leu-Alg-Pro-Gly-NH2.