| 摘要 |
A method for the preparation of a compound of the formula <IMAGE> or salt thereof bearing one or more alpha -hydroxymethylene groups, wherein the univalent moiety R is hydrogen, a straight chain or branched alkyl group of 1 to 20 carbon atoms, a straight chain or branched moiety of the formula -(CH2)n-COOR1, OR1, CF3, wherein n is from 0 to 5, a straight chain or branched moiety of the formula <IMAGE> wherein each R1 independently represents an alkyl radical of 1 to 12 carbon atoms, or a univalent phenol moiety and n has the meaning above, a substituted or unsubstituted moiety of the formula <IMAGE> wherein R2 is hydrogen, an alkyl group of 1 to 6 carbon atoms, a -(CH2)n-COOR1, chlorine, bromine, -OR1, CF3, -(CH2)n-CN, where n and R1 have the meanings given above, a ring system of the heterocyclic or isocyclic, monocyclic or polycyclic structure which comprises contacting a nitrile of the formula R-CH2-CN II wherein R has the meaning given above with carbon monoxide in the presence of an alcoholate and a solvent. Thereafter, the so formed salt can be separated or, if desired, the same can be converted into the free form of the compound Ia or Ib by acidification. Also disclosed are new alpha -hydroxymethylene and nitriles as well as their corresponding salts.
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