发明名称 |
Intravenously injectable solution of plasma protein fraction free from bradykinin, kininogen and prekallikrein activators and processes for its production |
摘要 |
Plasma Protein Fraction substantially free of bradykinin, kininogen and prekallikrein activators is obtained by treating Cohn Supernatant II plus III at about neutrality with a siliceous substance for a period of time sufficient to bring about essentially complete conversion of intrinsic kininogen into bradykinin. Subsequently, after being separated from Cohn Fraction IV-1, the Plasma Protein Fraction is reconstituted and held for a period of time sufficient to allow substantially complete destruction of bradykinin by kininase. Methods are disclosed for the destruction of prekallikrein activators which may be present in Plasma Protein Fraction.
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申请公布号 |
US4251510(A) |
申请公布日期 |
1981.02.17 |
申请号 |
US19790066757 |
申请日期 |
1979.08.15 |
申请人 |
CUTTER LABORATORIES, INC. |
发明人 |
TANKERSLEY, DONALD L. |
分类号 |
A61K38/00;C07K14/47;C07K14/765;(IPC1-7):A61K35/14;A61K37/00;C07G7/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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