发明名称 |
FREMGANGSMAADE TIL FREMSTILLING AF PENTAPEPTIDER MED VIRKNING PAA IMMUNSYSTEMET SAMT MELLEMPRODUKTER VED FREMGANGSMAADEN |
摘要 |
<p>The invention relates to a process for the preparation of peptides of the general formula Arg-Lys-S-Val-Y in which S denotes glutamic acid or alpha -aminoadipic acid and Y denotes tyrosine or tryptophan or esters or amides thereof, which comprises subjecting tetrapeptides of the formula Z-Arg(Z'2)-Lys(Z')-S-(Bzl)-Val-OH in which Z' represents a protective group of the benzyl type, to a condensation reaction with corresponding tyrosine esters or amides or tryptophan esters or amides and removing the protective groups by hydrogenation. The invention furthermore relates to tetrapeptides as intermediate products of this process.</p> |
申请公布号 |
DK254985(D0) |
申请公布日期 |
1985.06.06 |
申请号 |
DK19850002549 |
申请日期 |
1985.06.06 |
申请人 |
HOECHST AKTIENGESELLSCHAFT |
发明人 |
KOENIG WOLFGANG;GEIGER ROLF;OBERMEIER RAINER;MUELLNER HUBERT |
分类号 |
A61K38/00;A61K38/22;A61P37/00;C07K7/06;C07K14/66;(IPC1-7):C07K/ |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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