Novel apovincaminic acid derivatives

摘要

The invention relates to new racemic and optically active apovincaminic acid derivatives of the general formula (I) <IMAGE> (I) wherein A is hydroxyl, halogen or a group -O-(CH2)n-OR1 or -OMe, in which R1 is alkyl having from one to 6 carbon atoms, n is an integer between 2 and 6, Me is an alkali metal, R2 stands for an alkyl group having from one to 6 carbon atoms, which may be identical with or different from R1, and the hydrogen in the 3-position and the R2 group have an alpha , alpha - and/or beta , beta - or alpha , beta - and/or beta , alpha -configuration, and pharmaceutically acceptable acid addition salts thereof, which are pharmaceutically active, e.g. show antihypoxial activity or are potent peripheral vasodilators. Their preparation and pharmaceutical composition containing them are also within the scope of the invention.