| 摘要 |
Analogues of neurophypophysial hormones with inhibition properties of the general formula I <IMAGE> where all chiral amino acids are of the L-series and the aromatic amino acid in the position 2, indicated with an asterisk*, is of the D-series, and where R<1> and R<2> mean hydrogen or methyl group, R<3> means hydrogen, amino group, or a triglycylamine grouping, R<4> means hydrogen, methyl, ethyl or theoxyl, R<5> means a group S-CH2 or S-S, X<1> means a residue of isoleucine or phenylalanine, X<2> means a residue of leucine or lysine, and X<3> means a glycinamide residue or hydroxyl group, are described. These analogues exhibit inhibition effects towards the uterotonic and pressor activity of natural hormones. The common structural feature of all these analogues is the presence of an aromatic hydrophobic D-amino acid in the position 2. |
