| 摘要 |
<p>NEW MATERIAL:The compound of formula I [R<1> and R<2> are H, 1-4C alkyl or together with bonded N form 4-8-membered heterocyclic group; Z is group of formula II-formula V (R<3>-R<11> are H, 1-4C alkyl, alkyenyl or alkynyl, or R<3> and R<4>, R<5> and R<6>, R<7> and R<8>, or R<10>, R<11> together with bonded N form 4-8-membered heterocyclic group; p is 0-2), etc.]. EXAMPLE:1-Amino-2-[4-[4-(1-piperidinomethyl)pyridyl-2-oxy]-cis-2-buten ylami- no-]-1-cyclobutene-3,4-dione. USE:It has strong histamine H2 receptor-inhibiting action and gastric acid secretion-suppressing action, and is extremely useful as an antiulcer agent. PREPARATION:For example, the compound of formula I wherein Z is group of formula I can be prepared by reacting the compound of formula VI with the compound of formula VII (E is O or S; R<20> is alkyl), and reacting the resultant compound of formula VIII with an amine of formula HRR<3>R<4>.</p> |
