Crosslinked pressure-sensitive adhesives tolerant of alcohol-based excipients used in transdermal delivery devices and method of preparing same.

摘要

A crosslinked, acrylate-based pressure-sensitive adhesive is provided to obtain a creep compliance value of the pressure-sensitive adhesive of between 1.1 x 10<-><5> cm<2>/dyne to about 2.3 x 10<-><5> cm<2> /dyne in the presence of alcohol-based excipients, such as ethanol serving as a solvent or a penetration enchancing agent used with transdermal delivery devices. The method of preparing such crosslinked pressure-sensitive adhesive by using electron beam radiation of from 5 kGy to 200 kGy, and medical articles using the crosslinked pressure-sensitive adhesive as a layer therein to contact skin are also provided.