NOVEL METHODS FOR TESTING INHIBITORS OF PAIRED HELICAL FILAMENTS AND USES FOR TREATMENT OF ALZHEIMER'S DISEASE

摘要

The present invention relates to the use of inhibitors of intracellular polyanions, for example of RNA, poly-Glu or polyanionic polypeptides (tubulin or parts thereof), or derivatives thereof such as polycations or ribozyme, for the prevention or treatment of Alzheimer disease. In addition, the present invention relates to methods for testing inhibitors for their capacity to inhibit paired helical filaments formations and to kits useful in carrying out such methods.