| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject new compound havingβ-1,3-glucan synthase inhibitory activity and useful for preventing and treating fungal infectious diseases, carinii pneumonia. SOLUTION: This new cyclic hexapeptide (salt) is shown by formula I [R<1> is a lower alkanoyl substituted with (substituted) unsaturated sixmembered heteromonocyclic group(s) containing at least one nitrogen atom, lower alkanoyl substituted with (substituted) 1,2,3,4tetrahydroisoquinoline, lower alkanoyl substituted with (substituted) unsaturated condensed heterocyclie group(s) containing at least one oxygen atom, lower alkanoyl substituted with (substituted) unsaturated condensed heterocyclie group(s) containing at least two nitrogen atoms, etc.], having antimicrobial effect (in particular, antifungal effect) andβ1,3-glucan synthase inhibitory effect, therefore, being useful for preventing and treating fungal infectious diseases and carinii pneumonia. This new compound is obtained by reaction of a compound of formula II with a compound of the formula R<1> -OH.
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