发明名称 |
COMBINED THERAPY AGAINST TUMORS COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES, TAXANES AND/OR ANTIMETABOLITES |
摘要 |
The present invention provides the combined use of acryloyl distamycin derivatives, in particular alpha-bromo- and alpha-chloro-acryloyl distamycin derivatives of formula (I), as set forth in the specification, and antimicrotubule agents. Also provided is the use of the said combination in the treatment or prevention of metastasis or in the treatment of tumors by inhibition of angiogcncsis. |
申请公布号 |
PL200504(B1) |
申请公布日期 |
2009.01.30 |
申请号 |
PL20010363696 |
申请日期 |
2001.06.20 |
申请人 |
NERVIANO MEDICAL SCIENCES S.R.L. |
发明人 |
GERONI MARIA CRISTINA ROSA;COZZI PAOLO;BERIA ITALO |
分类号 |
A61K31/409;C07D305/14;A61K31/337;A61K31/40;A61K31/4025;A61K31/4155;A61K31/4178;A61K31/475;A61K31/505;A61K31/513;A61K31/519;A61K31/565;A61K31/7064;A61K31/7068;A61K31/7072;A61K45/06;A61P35/00;C07D207/456;C07D519/04 |
主分类号 |
A61K31/409 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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