METHOD OF PREPARING FOR PYRIDINE

摘要

A process for preparing pyridine derics. of formula (I) comprises (a) reacting 3,5-dimethyl pyridine-N-oxide of formula (II) with a halogenating agent to obtain 3,5-dimethyl-4-chloro pyridine of formula (III), and (b) reacting (III) with an oxidizing agent and a base. Pref. the halogenating agent is POCl3; the oxidizing agent is H2O2; the base is potassium methoxide. Cpds. (I) are intermediates in the prepn. of omeprazole which is useful as an antiulcer drug.