DELAYED RELEASE, ORAL DOSAGE COMPOSITIONS THAT CONTAIN AMORPHOUS BARDOXOLONE METHYL (CDDO-Me)

摘要

According to the present invention proposed are pharmaceutical formulations exhibiting a desirably low Cmax, among other properties, said formulations containing particles of amorphous bardoxolone methyl, either in pure form or in the form of a solid dispersion, admixed with particles of a hydrophilic binding agent. Such formulations possess the advantage of higher oral bioavailability, relative to formulations based on the crystalline form of bardoxolone methyl.