| 发明名称 |
Diagnostic BioMarkers for Fibrotic Disorders |
| 摘要 |
The present invention provides novel methods of inhibiting fibrosis, as well as methods of treating or inhibiting fibrotic disorders, using BMP9 and/or BMP10 antagonists. The present invention also provides methods of assessing whether a subject has or is at risk of developing a fibrotic disorder by detecting levels of BMP9 and/or BMP10. Further provided are methods of assessing the efficacy of a treatment regimen for treating a fibrotic disorder by detecting and comparing pre-treatment levels of BMP9 and BMP10 with post-treatment levels of BMP9 and BMP10. |
| 申请公布号 |
US2016228509(A9) |
申请公布日期 |
2016.08.11 |
| 申请号 |
US201313852079 |
申请日期 |
2013.03.28 |
| 申请人 |
Buckler Alan;Chen Chao-Min;Guy Chantale T.;Hewett Jeffrey;Lu Chris;Wu Jing |
发明人 |
Buckler Alan;Chen Chao-Min;Guy Chantale T.;Hewett Jeffrey;Lu Chris;Wu Jing |
| 分类号 |
A61K38/18;A61K38/16;A61K31/7088;A61K45/06;A61K39/395;G01N33/50 |
主分类号 |
A61K38/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of inhibiting fibrosis in a cell, comprising contacting said cell with an effective amount of a BMP9 or BMP10 antagonist, thereby inhibiting fibrosis in said cell. |
| 地址 |
Arlington MA US |
