CELL SURFACE RECEPTORS HOMOLOGOUS TO COAGULATION FACTORS V AND VIII

摘要

2105993 9216558 PCTABS00016 A new class of cellular receptors extensively homologous but not identical to coagulation factors V and VIII is identified. Specific amino acid residue sequences of the receptor are described. Antibody compositions capable of immunoreacting with polypeptides containing the identified amino acid residue sequences and related diagnostic protocols are also described. The receptors are demonstrated to bind coagulation factor Xa which binding is inhibited by monoclonal antibodies to the receptors.