BENZOHETEROCYCLICALKYL DERIVATIVES OF 4-(2-KETO -1-BENZIMIDAZOLINYL)-PIPERIDINE 4-(2-KETO - 1 - BENZIMIDAZOLINYL) -1 2 3 6 TETRAHYDROPYRIDINE 1 - PHENYL - 1 3 8-TRIAZASPIRO(4 5)DECAN - 4 - ONE AND 2 4 9-TRIAZASPIRO(5 5)UNDECAN-1 3 5-TRIONE

摘要

Benzoheterocyclic-alkyl derivatives of 1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one in which the benzoheterocyclic moiety is thianaphthenyl or benzofuranyl, optionally substituted by chloro, bromo, fluoro, methyl, methoxy or trifluoromethyl, have neuroleptic activity. The compounds are generally prepared from either the benzo-heterocyclicalkyl halide by reaction with the appropriate amine or the benzoheterocyclic amine by condensation with a 5,5-bis ( beta -haloethyl) barbituric acid.